A Croncise Organocatalytic Route to Protected (2S, 4R)-4-Hydroxyornithine and(+)-Pseudohygroline

作者：Jha Vishwajeet; Kumar Pradeep^*

来源：Synlett, 2014, 25(8): 1089-1092.

DOI：10.1055/s-0033-1340977

• aldehydes
• amination
• amino alcohols
• Wittig reaction
• cyclization
• enantioselectivity

A practical, efficient, and organocatalytic approach to the synthesis of (2S,4R)-4-hydroxyornithine and (+)-pseudohygroline is reported using proline-catalyzed sequential alpha-aminoxylation/alpha-amination reaction and Horner-Wadsworth-Emmons olefination reaction of an aldehyde as the key step.

• 出版日期2014-5-16