Autophagic control of listeria through intracellular innate immune recognition in drosophila

作者：Yano Tamaki; Mita Shizuka; Ohmori Hiroko; Oshima Yoshiteru; Fujimoto Yukari; Ueda Ryu; Takada Haruhiko; Goldman William E; Fukase Koichi; Silverman Neal; Yoshimori Tamotsu; Kurata Shoichiro^*

来源：Nature Immunology, 2008, 9(8): 908-916.

DOI：10.1038/ni.1634

Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic components, has been linked to the elimination of intracellular pathogens during mammalian innate immune responses. However, the mechanisms underlying cytoplasmic infection-induced autophagy and the function of autophagy in host survival after infection with intracellular pathogens remain unknown. Here we report that in drosophila, recognition of diaminopimelic acid-type peptidoglycan by the pattern-recognition receptor PGRP-LE was crucial for the induction of autophagy and that autophagy prevented the intracellular growth of Listeria monocytogenes and promoted host survival after this infection. Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense.

• 出版日期2008-8