A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry

作者：Joshita Satoru^*; Nakazawa Koh; Koike Shoichiro; Kamijo Atsushi; Matsubayashi Kiyoshi; Miyabayashi Hideharu; Furuta Kiyoshi; Kitano Kiyoshi; Yoshizawa Kaname; Tanaka Eiji

来源：Journal of Korean Medical Science, 2010, 25(3): 476-480.

DOI：10.3346/jkms.2010.25.3.476

• G-CSF-producing Tumor
• Carcinoma, Hepatocellular, Immunohistochemistry

Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing malignant tumors have been published, but scarcely any in the hepatobiliary system, such as in hepatocellular carcinoma (HCC). Here, we encountered a 69-yr-old man with a hepatic tumor who had received right hepatic resection. He showed leukocytosis of 25,450/mL along with elevated serum G-CSF. Histological examination of surgical samples demonstrated immunohistochemical staining for G-CSF, but not for G-CSF receptor. The patient survived without recurrence for four years, but ultimately passed away with multiple bone metastases. In light of the above, clinicians may consider G-CSF-producing HCC when encountering patients with leukocytosis and a hepatic tumor. More cases are needed to clarify the clinical picture of G-CSF-producing HCC.

• 出版日期2010-3