Novel Method for Synthesizing Spiro[4.5]cyclohexadienones through a Pd-Catalyzed Intramolecular ipso-Friedel-Crafts Allylic Alkylation of Phenols

作者:Nemoto Tetsuhiro; Ishige Yuta; Yoshida Mariko; Kohno Yuta; Kanematsu Mutsumi; Hamada Yasumasa*
来源:Organic Letters, 2010, 12(21): 5020-5023.
DOI:10.1021/ol102190s

摘要

The first successful Pd-catalyzed intramolecular ipso-Friedel Crafts allylic alkylation of phenols, which provided a new access to spiro[4.5]cyclohexadienones, is described. The present method could be applied to catalytic enantioselective construction of an all-carbon quaternary spirocenter.

  • 出版日期2010-11-5