科研之友
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摘要
IntroductionAntimicrobial resistance is a growing concern with implications for animal health. This study investigated the prevalence of antimicrobial resistance among commensal and environmental Escherichia coli isolated from animals sampled in referral hospitals in the UK. Materials and MethodsResistant Escherichia coli isolated from animal faeces and practice environments were tested for susceptibility to antimicrobial agents. PCR and sequencing techniques were used to identify extended spectrum beta-lactamase and AmpC-producer genotypes. ResultsIn total, 333 faecal and 257 environmental samples were collected. Multi-drug resistant Escherichia coli were found in 131% of faecal and 89% of environmental samples. Extended spectrum beta-lactamase and AmpC genes were identified 14% and 77% of faecal samples and 86% and 86% of environmental samples, respectively. The most common extended spectrum beta-lactamase gene type detected was bla(CTX-M -15), although bla(TEM-158) was detected in faecal and environmental samples from one practice. Clinical SignificanceEscherichia coli resistant to key antimicrobials were isolated from hospitalised animals and the practice environment. We identified the emergence of the inhibitor resistant and extended spectrum beta-lactamase bla(TEM-158) in companion animals. Further investigation to determine risk factors for colonisation with antimicrobial-resistant bacteria is needed to provide evidence for antimicrobial stewardship and infection control programmes.
- 出版日期2016-7
