Development, Characterization, and Cellular Adhesion of Poly(L-Lactic Acid)/Poly(Caprolactone Triol) Membranes for Potential Application in Bone Tissue Regeneration

作者：Mistura Daniel V; Messias Andre D; Duek Eliana A R; Duarte Marcia A T^*

来源：Artificial Organs, 2013, 37(11): 978-984.

DOI：10.1111/aor.12232

Poly(L-lactide)/poly(caprolactone triol) (PLLA/PCL-T) membranes were prepared by solution casting in 100/0, 90/10, and 70/30 (w/w) ratios. The membranes were analyzed by dynamic mechanical analysis, differential scanning calorimetry, and mechanical tests. The thermal analysis showed that the 90/10 and 70/30 preparations were partly miscible systems. The glass transition temperature (T-g) of PLLA decreases as the PCL-T concentration increases, which implies that PCL-T has a plasticizer function. An in vitro study with osteoblastic cells isolated from the calvariae of rats was performed in all preparations. The results obtained in this study showed that the addition of PCL-T to the PLLA matrix modifies its mechanical, thermal, and biological properties. These blends could be useful for tissue engineering for bone applications.

• 出版日期2013-11