Aggregation and Solvation of n-Butyllithium

作者：Tai Onkei; Hopson Russell; Williard Paul G^*

来源：Organic Letters, 2017, 19(15): 3966-3969.

DOI：10.1021/acs.orglett.7b01644

Solution characterizations and ligand binding constants were determined for n-butyllithium in hydrocarbon and ethereal solvents using diffusion-ordered NMR. In hydrocarbon solvents, n-butyllithium exists primarily as an octamer at -40 degrees C and deaggregates to a hexamer when the temperature is increased. In the presence of THF or diethyl ether, n-butyllithium exists predominantly as a tetra-solvated tetramer and deaggregates to a tetra-solvated dimer in the presence of a large excess or neat THF. The ligand binding constants for the tetra-solvated tetramers were measured using H-1 NMR/DOSY titration.

• 出版日期2017-8-4