A solvent-free protocol for facile condensation of indoles with carbonyl compounds using silica chloride as a new, highly efficient, and mild catalyst

作者：Hasaninejad Alireza^*; Zare Abdolkarim; Sharghi Hashem; Shekouhy Mohsen; Khalifeh Reza; Beni Alireza Salimi; Zare Ahmad Reza Moosavi

来源：Canadian Journal of Chemistry, 2007, 85(6): 416-420.

DOI：10.1139/V07-051

• silica chloride
• indole
• carbonyl compound
• solvent-free
• bis(indolyl)methane

A simple and efficient solvent-free procedure for the preparation of bis(indolyl)methanes via electrophilic substitution reactions of indoles with aldehydes and ketones is described. The reactions took place in the presence of a catalytic amount of silica chloride at room temperature. The advantages of this method are high yields, short reaction times, low cost, and compliance with green-chemistry protocols.

• 出版日期2007-6