科研之友
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摘要
The enantioselective hydrogenation of prochiral ketones using H(2) as reducing agent is a valuable method of producing chiral alcohols as intermediates for the pharmaceutical and fine chemical industry. Iridium-based catalysts are of increasing interest in this innovative field. We present herein a new lead structure. The novel phosphorus-free N,N,OH ligand stabilised iridium complexes are able to hydrogenate simple ketones with excellent enantioselectivities under mild conditions. The catalysts were easily synthesised from air and moisture stable reactants and have a great commercial potential. The modular nature ensures the introduction of a broad variety of substitution patterns.
- 出版日期2011-10
