Preparation of thin polymer films with controlled drug release

作者：Tsukagoshi Tatsuya; Kondo Yukishige; Yoshino Norio^*

来源：Colloids and Surfaces B: Biointerfaces , 2007, 57(2): 219-225.

DOI：10.1016/j.colsurfb.2007.02.005

• surface modification
• controlled drug release
• silane
• contact angle
• poly(N-isopropylacrylamide)

Poly(N-isopropylacrylamide) (PAAm) is a thermal responsive polymer that undergoes a structural change in aqueous solution at its lower critical solution temperature (LCST). PAAm-modified silicon substrates were prepared and the effect of PAAm density on the thermal response of the modified surface was examined in terms of changes in the water contact angle as a basis for applying the structural change of the polymer to controlled drug release. Changes with temperature in the ability to load and release of the modified layer for drug were also examined using 2-acetoxybenzoic acid (aspirin) as a model drug. The amount of PAAm was found to greatly affect the thermal response and the ability to load and release of the modified layer for aspirin.

• 出版日期2007-6-15