Nephrotic Syndrome Related to Chronic Neutrophilic Leukemia

作者：Wang, Rending; Tong, Hongyan; Wang, Huiping; Chen, Zhimin; Wang, Lijun; Chen, Jianghua^*

来源：Internal Medicine, 2014, 53(21): 2505-2509.

DOI：10.2169/internalmedicine.53.2162

• chronic neutrophilic leukemia
• nephrotic syndrome
• focal segmental glomerulosclerosis

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm. We herein describe the case of a 41-year-old woman who was admitted with nephrotic syndrome (NS) and severe neutrophilia and underwent a splenectomy due to splenomegaly. Peripheral blood tests revealed a Janus kinase 2 (JAK2) V617F mutation without the Philadelphia chromosome, BCR-ABL fusion transcripts, or FIP1 L1-platelet-derived growth factor (PDGF) a. A kidney biopsy showed focal segmental glomerulosclerosis (FSGS) with interstitial neutrophil infiltration and with a JAK2 V617F mutation. Hydroxyurea was initiated for first three months, followed by hydroxyurea plus interferon, and a subsequent improvement in leukocytosis and completely remission of FSGS-NS was immediately noted. This is the first case reported in which NS was related to CNL.

• 出版日期2014
• 单位浙江大学