A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib

作者：Peng, Jin Yong^*; Liu, Hai Yan; Qi, Yan; Han, Xu; Xu, You Wei; Xu, Li Na; Xu, Qi Wei

来源：Chinese Chemical Letters, 2007, 18(3): 293-296.

DOI：10.1016/j.cclet.2007.01.007

• Dolichos tenuicaulis (Baker) Craib
• prenylated dihydroflavonoid
• anticancer activity

A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2',6'-trihydroxy-3 ''', 8-di (gamma, gamma-dimethyl-allyl)-2''', 2'''-dimethylpyrano-[5''',6''': 6,7]-2''''',4'''''-cyclohexadiene-1'''''-one-[''''',3''''': 3',4']-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, ID NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells' growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro.

• 出版日期2007-3
• 单位大连医科大学