A highly chemo- and enantioselective nitroaldol reaction of haloenals: preparation of chiral functionalized allylic alcohols

作者：Gu Lianghu; Zhou Yirong; Zhang Jingli; Gong Yuefa^*

来源：Tetrahedron: Asymmetry , 2012, 23(2): 124-129.

DOI：10.1016/j.tetasy.2012.01.011

An efficient L1/Cu(II)-catalyzed highly chemoselective and enantioselective nitroaldol reaction of alpha- or beta-haloenals with nitromethane has been described. The reaction delivered chiral functionalized allylic alcohols bearing halo and nitro groups with excellent results (up to 94% yield and 99% ee) under mild reaction conditions.

• 出版日期2012-1-31
• 单位华中科技大学