科研之友
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摘要
Purpose Correlate OCT-derived measures of drusen and retinal pigment epithelium (RPE) atrophy areas (RAs) with demographic features in an elderly population. Patients and methods Subjects aged 50 years and older underwent Cirrus OCT scanning. Drusen area and volume were obtained from the macula within a central circle (CC) of 3mm and a surrounding perifoveal ring (PR) of 3-5 mm, using the RPE analysis software (6.0). RA measurements were generated for the 6 x 6mm(2) retinal area. Gender, age, smoking status, and systolic blood pressure (SBP) were considered. Results A total of 434 eyes were included. RA was larger in women (0.63 +/- 0.16 vs 0.26 +/- 0.08 mm(2), P = 0.05) and with increasing age. The PR drusen area increased with increasing age (P<0.001), whereas the CC drusen area remained stable after the age of 70 years (0.25 +/- 0.06mm(2) for ages 70-79 years and 0.25 +/- 0.07mm(2) for ages 480 years). Drusen volume in the CC was smaller after the age of 80 years (0.009 +/- 0.003mm 3) compared with the 70- to 79-year-old group (0.02 +/- 0.008mm 3). Drusen measurements were similar between smokers and nonsmokers, but the PR drusen area (0.29mm(2), P = 0.05) and volume (0.40mm(3), P = 0.005) were correlated with years smoked. RA (0.24mm(2), P = 0.10), PR drusen area (0.29mm(2), P = 0.05), and volume (0.40mm(3), P = 0.005) were found to be directly associated with SBP. There was a high correlation between the eyes of the same subject. Conclusion OCT-based automated algorithms can be used to analyze and describe drusen and geographic atrophy burden in such population-based studies of elderly patients.
- 出版日期2015-2
