Highly dispersed nanoscale hydroxyapatite on cellulose nanofibers for bone regeneration

作者：Yamaguchi Kyohei; Prabakaran Mayakrishnan; Ke Ma; Gang Xu; Chung Ill Min; Um In Chul; Gopiraman Mayakrishnan^*; Kim Ick Soo^*

来源：Materials Letters, 2016, 168: 56-61.

DOI：10.1016/j.matlet.2016.01.010

• Electrospinning
• Cellulose nanofibers
• Hydroxyapatite
• Bone regeneration
• Nanocomposites

A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1 cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration.

• 出版日期2016-4-1