Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction

作者：Smith Patrick J; Blumenthal James A; Babyak Michael A; Georgiades Anastasia; Sherwood Andrew; Sketch Michael H Jr; Watkins Lana L^*

来源：American Journal of Clinical Nutrition, 2009, 89(5): 1315-1320.

DOI：10.3945/ajcn.2008.26829

Background: n-3 (omega-3) Fatty acids are associated with a reduced risk of cardiovascular disease; however, the relation between dietary intake of n23 fatty acids and ventricular arrhythmias has not been investigated among acute post-myocardial infarction (AMI) patients-a group at elevated risk of malignant arrhythmias.
Objective: The objective was to examine the association between n-3 fatty acid consumption and ventricular ectopy among AMI patients.
Design: In 260 AMI patients, dietary intake of n-3 fatty acids was assessed by using the Harvard food-frequency questionnaire, and ventricular ectopy was estimated from 24-h electrocardiograph recordings.
Results: A greater intake of n-3 fatty acids ( eicosapentaenoic acid docosahexaenoic acid docosapentaenoic acid alpha-linolenic acid) was associated with lower ventricular ectopy (beta = -0.35, P=0.011), and this effect remained after cardiovascular comorbidities were controlled for (beta = -0.47, P = 0.003). Higher concentrations of both marine-based (eicosapentaenoic acid 1 docosahexaenoic acid) (beta = -0.21, P = 0.060) and plant-based (alpha-linolenic acid) (beta = -0.33, P = 0.024) fatty acids remained associated with lower ventricular ectopy after cardiovascular comorbidities were controlled for.
Conclusion: These findings extend existing evidence linking n-3 fatty acid consumption to a reduced risk of ventricular arrhythmias by showing that a greater intake of n-3 fatty acids may be associated with low ventricular ectopy among AMI patients. Am J Clin Nutr 2009;89:1315-20.

• 出版日期2009-5-1