A case of esophageal adenocarcinoma on long-term rapamycin monotherapy

作者：Canha Catarina; Ferreira Raquel; Rovira Jordi; Moya Rull Daniel; Castells Antoni; Diekmann Fritz; Oppenheimer Federico; Maria Campistol Josep; Revuelta Ignacio^*

来源：Transplant International, 2015, 28(10): 1240-1244.

DOI：10.1111/tri.12600

• immunosuppression
• immunosuppression clinical
• kidney clinical
• malignancies and long term compliations
• molecular diagnostic
• solid tumors
• TOR-inhibitors

Cancer in transplant recipients represents a therapeutic challenge even when the patient is already under mTOR inhibitors. A 78-year-old man received a deceased donor kidney transplant in 1993. After 6months, he developed a multifocal cutaneous and nonvisceral Kaposi's Sarcoma while on cyclosporine immunosuppressant therapy. The patient was converted to sirolimus monotherapy in 2001 with subsequent complete recovery within 2years. In 2007, the patient was diagnosed with an esophageal adenocarcinoma stage IIA. An esophagectomy was performed without requirement of further treatment. He has continued on sirolimus monotherapy ever since, with no other incidents and no recurrences of either tumor. In this report, we describe an interesting case of a second cancer while on immunosuppressive therapy with anticancer activity. Moreover, the present knowledge of the matter is discussed.

• 出版日期2015-10