Aurora A kinase (AURKA) in normal and pathological cell division

作者：Nikonova Anna S; Astsaturov Igor; Serebriiskii Ilya G; Dunbrack Roland L Jr; Golemis Erica A^*

来源：Cellular and Molecular Life Sciences, 2013, 70(4): 661-687.

DOI：10.1007/s00018-012-1073-7

• Aurora A
• AURKA
• Cancer
• Mitosis
• Cell cycle
• Kinase
• Centrosome
• Cilia

Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and cytokinesis. Genetic amplification and mRNA and protein overexpression of Aurora A are common in many types of solid tumor, and associated with aneuploidy, supernumerary centrosomes, defective mitotic spindles, and resistance to apoptosis. These properties have led Aurora A to be considered a high-value target for development of cancer therapeutics, with multiple agents currently in early-phase clinical trials. More recently, identification of additional, non-mitotic functions and means of activation of Aurora A during interphase neurite elongation and ciliary resorption have significantly expanded our understanding of its function, and may offer insights into the clinical performance of Aurora A inhibitors. Here we review the mitotic and non-mitotic functions of Aurora A, discuss Aurora A regulation in the context of protein structural information, and evaluate progress in understanding and inhibiting Aurora A in cancer.

• 出版日期2013-2