Parental hay fever reinforces IgE to pollen as pre-clinical biomarker of hay fever in childhood

作者：Hatzler Laura; Panetta Valentina; Illi Sabina; Hofmaier Stephanie; Rohrbach Alexander; Hakimeh Dani; Bauer Carl P; Hoffman Ute; Forster Johannes; Zepp Fred; Schuster Antje; Stock Philippe; Wahn Ulrich; Keil Thomas; Lau Susanne; Matricardi Paolo M^*

来源：Pediatric Allergy and Immunology, 2014, 25(4): 366-373.

DOI：10.1111/pai.12248

• birch and grass pollen
• immunoglobulin E
• prediction
• risk factors
• seasonal allergic rhinitis

Background: An early IgE response to grass or birch pollen can anticipate seasonal allergic rhinitis to pollen later in life or remain clinically silent. %26lt;br%26gt;Objective: To identify risk factors early in life that allow discriminating pathogenic from non-pathogenic IgE responses and contribute to the development of seasonal allergic rhinitis to grass pollen. %26lt;br%26gt;Methods: The German Multicentre Allergy Study examined a birth cohort born in 1990. A questionnaire was yearly administered and blood samples collected at age 1,2,3,5,6,7,10,13 yr. The definition of the primary outcome grass-and birch-pollen-related seasonal allergic rhinitis (SARg, SARb) was based on nasal symptoms in June/July and April, respectively. Serum IgE antibodies to Phleum pratense and Betula verrucosae extracts were monitored with immune-enzymatic singleplex assays. %26lt;br%26gt;Results: Of the 820 examined children, 177 and 148 developed SARg and SARb, respectively. Among healthy children aged 3 or more years, IgE to grass pollen was the strongest risk factor of SARg (OR 10.39, 95% CI 6.1-17.6, p %26lt; 0.001), while parental hay fever was the only risk factor in early childhood independently associated with future SARg (1 parent: OR 2.56, 95% CI 1.4-4.5, p %26lt; 0.001; 2 parents: OR 4.17, 95% CI 1.7-10.1) and SARb (1 parent OR: 5.21, 95% CI 2.20-12.4, p %26lt; 0.001; 2 parents: OR 8.02, 95% CI 2.0-32.9, p %26lt; 0.001). Parental hay fever was associated with an increase of the concentration of pollen-specific IgE in seropositive subjects, after the age of 6 and was also a hallmark of molecularly more complex specific IgE responses to grass or birch pollen at age 6 or older. %26lt;br%26gt;Conclusions: Parental hay fever and specific IgE to grass and/or birch pollen are strong pre-clinical determinants and potentially good predictors of seasonal allergic rhinitis.

• 出版日期2014-6