科研之友
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摘要
Development of highly efficient and enantioselective hydrophosphonylations of aldehydes and ynones mediated by [5.5]P-spirocyclic chiral triaminoiminophosphoranes as base catalysts is described. The strong basicity of the iminophosphoranes and hydrogen-bond donating ability of their conjugate acids, tetraaminophosphonium ions, are critical for the facile generation of aminophosphonium phosphites with substantial nucleophilicity as well as for the subsequent selective, yet productive, P-C bond formation by suppressing undesired side reactions. The scope and limitations of these catalytic asymmetric methodologies are also reported.
- 出版日期2017-5
