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摘要
The cyclotriphosphazene derivative N3P3[OC6H4-p-CH2O(CO)CHCH(CO)OH](6) bearing maleic acid groups was synthesized and characterized by NMR, FTIR spectroscopy, and MS. A cross-linked network was produced by free radical copolymerization of this phosphazene derivative with N-vinyl-2-pyrrolidone (NVP). Swelling experiments indicated that the cross-linked network was highly sensitive to pH environments. In vitro release studies have been performed in 2.0 and 7.4pH media to simulate gastric and intestinal conditions. The results indicated a dependence on the pH of the release media and extent of crosslinking.
