Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum

作者：Cheng, Shi Yie; Wang, Shang Kwei; Duh, Chang Yih^*

来源：Marine Drugs, 2014, 12(12): 6028-6037.

DOI：10.3390/md12126028

• Lobophytum crassum
• seco-cembranoid
• Mosher's acylation
• antiviral activity

Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher's acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 mu g/mL.

• 出版日期2014-12
• 单位中山大学