A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2] Rotaxane

作者：Bao, Xiaofeng^*; Shi, Jiaxin; Zhu, Jing; Wang, Xinlong^*

来源：Sensors and Actuators B: Chemical , 2016, 237: 380-386.

DOI：10.1016/j.snb.2016.06.140

• Rhodamine B
• Graphene oxide
• Nanocomposite sensor
• Doxorubicin
• Rotaxane

Graphene oxide (GO) displays advantageous characteristics as a quencher due to its excellent quenching capacity toward organic fluorescent molecules. In this paper, GO is used as a quencher of RhBPy [2]rotaxane based on the mechanism of fluorescence resonance energy transfer (FRET), and a GO-based fluorescent probe that allows rapid, sensitive and selective detection of doxorubicin (DOX) in a MeOH/H2O solution is reported. The results show that the efficient fluorescence quenching that occurs between GO and RhBPy [2]rotaxane is due to their strong noncovalent interactions via energy transfer, leading to very weak emission in the absence of DOX, while a strong red fluorescence is observed upon the addition of DOX into the RhBPy-GO solution. As a consequence, it is possible to employ the RhBPy-GO platform in DOX detection with high sensitivity and selectivity by monitoring changes in the fluorescence intensity of the MeOH/H2O (3:2, v: v) solution.

• 出版日期2016-12
• 单位南京中医药大学; 南京理工大学