Angiopoietin-1 elicits pro-inflammatory responses in monocytes and differentiating macrophages

作者：Seok Seung Hyeok; Heo Jong Ik; Hwang Ji Hye; Na Yi Rang; Yun Jang Hyuk; Lee Eun Hui; Park Jong Wan; Cho Chung Hyun^*

来源：Molecules and Cells, 2013, 35(6): 550-556.

DOI：10.1007/s10059-013-0088-8

• angiopoietin
• inflammation
• macrophage
• monocyte
• Tie2

The angiopoietin/Tie2 system is an important regulator of angiogenesis and inflammation. In addition to its functions in endothelial cells, Tie2 expression on non-endothelial cells allows for angiopoietin ligands to stimulate the cells. Although Ang1 is a strong Tie2 receptor agonist, little is known regarding the effect of Ang1 on non-endothelial cells, such as monocytes and macrophages. In this study, we found that Ang1 functionally binds to and stimulates monocytes via p38 and Erk1/2 phosphorylation. Ang1-mediated monocyte stimulation is associated with proinflammatory cytokine TNF-alpha expression. We also determined that Ang1 switched macrophage differentiation toward a pro-inflammatory phenotype, even in the presence of an anti-inflammatory mediator. These findings suggest that Ang1 plays a role in stimulating pro-inflammatory responses and could provide a new strategy by which to manage inflammatory responses.

• 出版日期2013-6