Acute Kidney Injury in Older Adults

作者：Anderson Sharon; Eldadah Basil; Halter Jeffrey B; Hazzard William R; Himmelfarb Jonathan; Horne Frances McFarland; Kimmel Paul L; Molitoris Bruce A; Murthy Mahadev; O'Hare Ann M; Schmader Kenneth E; High Kevin P^*

来源：Journal of the American Society of Nephrology, 2011, 22(1): 28-38.

DOI：10.1681/ASN.2010090934

Aging kidneys undergo structural and functional changes that decrease autoregulatory capacity and increase susceptibility to acute injury. Acute kidney injury associates with duration and location of hospitalization, mortality risk, progression to chronic kidney disease, and functional status in daily living. Definition and diagnosis of acute kidney injury are based on changes in creatinine, which is an inadequate marker and might identify patients when it is too late. The incidence of acute kidney injury is rising and increases with advancing age, yet clinical studies have been slow to address geriatric issues or the heterogeneity in etiologies, outcomes, or patient preferences among the elderly. Here we examine some of the current literature, identify knowledge gaps, and suggest potential research questions regarding acute kidney injury in older adults. Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury.

• 出版日期2011-1