Molecular Imaging of Immunotherapy Targets in Cancer

作者：Ehlerding Emily B; England Christopher G; McNeel Douglas G; Cai Weibo

来源：Journal of Nuclear Medicine, 2016, 57(10): 1487-1492.

DOI：10.2967/jnumed.116.177493

• PD-1
• PD-L1
• CTLA-4
• immune checkpoints
• immunotherapy
• positron emission tomography (PET)

Immunotherapy has emerged as a promising alternative in the arsenal against cancer by harnessing the power of the immune system to specifically target malignant tissues. As the field of immunotherapy continues to expand, researchers will require newer methods for studying the interactions between the immune system, tumor cells, and immunotherapy agents. Recently, several noninvasive imaging strategies have been used to map the biodistribution of immune checkpoint molecules, monitor the efficacy and potential toxicities of the treatments, and identify patients who are likely to benefit from immunotherapies. In this review, we outline the current applications of noninvasive techniques for the preclinical imaging of immunotherapy targets and suggest future pathways for molecular imaging to contribute to this developing field.

• 出版日期2016-10