Shorter telomere length is linked to brain atrophy and white matter hyperintensities

作者：Wikgren Mikael^*; Karlsson Thomas; Soderlund Hedvig; Nordin Annelie; Roos Goran; Nilsson Lars Goran; Adolfsson Rolf; Norrback Karl Fredrik

来源：Age and Ageing, 2014, 43(2): 212-217.

DOI：10.1093/ageing/aft172

• brain atrophy
• older people
• telomere length
• white matter hyperintensities

Background: leukocyte telomere length (TL) is considered a marker of biological aging. Several studies have investigated the link between leukocyte TL and aging-associated functional attributes of the brain, but no prior study has investigated whether TL can be linked to brain atrophy and white matter hyperintensities (WMHs); two prominent structural manifestations of brain aging.
Methods: we investigated whether leukocyte TL was related to brain atrophy and WMHs in a sample of 102 non-demented individuals aged 64-75 years.
Results: shorter TL was related to greater degree of subcortical atrophy (beta = -0.217, P = 0.034), but not to cortical atrophy. Furthermore, TL was 371 bp shorter (P = 0.041) in participants exhibiting subcortical WMHs, and 552 bp shorter (P = 0.009) in older participants exhibiting periventricular WMHs.
Conclusion: this study provides the first evidence of leukocyte TL being associated with cerebral subcortical atrophy and WMHs, lending further support to the concept of TL as a marker of biological aging, and in particular that of the aging brain.

• 出版日期2014-3