A prospective study of the impact of diabetes mellitus on restrictive and obstructive lung function impairment: The Saku study

作者：Sonoda Nao^*; Morimoto Akiko; Tatsumi Yukako; Asayama Kei; Ohkubo Takayoshi; Izawa Satoshi; Ohno Yuko

来源：Metabolism-Clinical and Experimental, 2018, 82: 58-64.

DOI：10.1016/j.metabol.2017.12.006

• Diabetes mellitus
• Restrictive lung function impairment
• Obstructive lung function impairment

Background. To assess the impact of diabetes on restrictive and obstructive lung function impairment.
Methods. This 5-year prospective study included 7524 participants aged 40-69 years without lung function impairment at baseline who underwent a comprehensive medical check-up between April 2008 and March 2009 at Saku Central Hospital. Diabetes was defined by fasting plasma glucose >= 7.0 mmo1/1 (126 mg/dl), HbAlc >= 6.5% (48 mmol/mol), or a history of diabetes, as determined by interviews conducted by the physicians. Restrictive and obstructive lung function impairment were defined as forced vital capacity (FVC) <80% predicted and forced expiratory volume in 1 s (FEV1) to FVC ratio (FEV1/FVC) <0.70, respectively. Participants were screened until they developed restrictive or obstructive lung function impairment or until March 2014.
Results. During the follow-up period, 171 and 639 individuals developed restrictive and obstructive lung function impairment, respectively. Individuals with diabetes had a 1.6-fold higher risk of restrictive lung function impairment than those without diabetes after adjusting for sex, age, height, abdominal obesity, smoking status, exercise habits, systolic blood pressure, HDL-cholesterol, log-transformed high-sensitivity C-reactive protein, and baseline lung function [multivariable-adjusted HR and 95% CI; 1.57 (1.04-2.36)]. In contrast, individuals with diabetes did not have a significantly higher risk of obstructive lung function impairment [multivariable-adjusted HR and 95% CI; 0.93 (0.72-1.21)].
Conclusion. Diabetes was associated with restrictive lung function impairment but not obstructive lung function impairment.

• 出版日期2018-5