Determination of Am-241 in urine using sector field inductively coupled plasma mass spectrometry (SF-ICP-MS)

作者：Xiao Ge^*; Saunders David; Jones Robert L; Caldwell Kathleen L

来源：Journal of Radioanalytical and Nuclear Chemistry, 2014, 301(1): 285-291.

DOI：10.1007/s10967-014-3103-4

• Am-241 determination
• Solid phase extraction (Eichrom DGA cartridge)
• Sector field inductively coupled plasma mass spectrometer (SF-ICP-MS)
• Clinical decision guide (CDG)
• Emergency response

Quantification of Am-241 in urine at low levels is important for assessment of individuals' or populations' accidental, environmental, or terrorism-related internal contamination, but no convenient, precise method has been established to rapidly determine these low levels. Here we report a new analytical method to measure Am-241 as developed and validated at the Centers for Disease Control and Prevention (CDC) by means of the selective retention of Am from urine directly on DGA resin, followed by SF-ICP-MS detection. The method provides rapid results with a limit of detection (LOD) of 0.22 pg/L (0.028 Bq/L), which is lower than 1/3 of the C/P CDG for Am-241 at 5 days post-exposure. The results obtained by this method closely agree with CDC values as measured by liquid scintillation counting, and with National Institute of Standards Technology (NIST) Certified Reference Materials (CRM) target values.

• 出版日期2014-7