科研之友
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摘要
Polypropylene (PP) is the most widely used biomaterial for hernia repair despite its many problems related to over fibrosis. The current study is designed to evaluate and directly compare the biomechanics and anti-adhesion properties of the novel, TEMPO(2,2,6,6-tetramethylpyperidine-1-oxyl)-mediated modified bacterial cellulose (TBC) mesh and the clinically used PP meshes. Laser perforation generates isotropic, flat and stable structures that prevent deformation under pressure and reduce the risk of potential bacterial colonization. In contrast to the PP mesh, the results of the in vitro study, which involve protein adsorption and cell-material interaction, suggest that TBC preferentially adsorbs bovine serum albumin (BSA) and enhances the expression of type I collagen in fibroblasts. TBC mesh cause less inflammation and is surrounded by newly formed connective tissue composed of type I collagen after implantation in a rabbit model for 1 week, demonstrating that the novel mesh is fully biocompatible and can integrate into surrounding tissues. From this study, TBC mesh may prove to be a viable clinical alternative to existing materials.
