Device for Controlled Distribution of FePt Nanoparticles Formations in a Stream of Liquid Medium under Influence of Magnetic Field

作者：Sileika Karolis; Kitamoto Yoshitaka; Baksys Bronius; Skiedraite Inga^*

来源：Materials Science-Medziagotyra, 2014, 20(1): 30-35.

DOI：10.5755/j01.ms.20.1.3371

• FePt nanoparticles
• Halbach array
• magnetic drug targeting
• magnetic particles flow

In this research paper a design of magnetic device comprising Halbach arrays which maximizes the magnetic forces acting on magnetic nanoparticles and which can be used for successful steering of said particles to a zone of interest and captured thereat while exhibiting a certain flow and accumulation pattern after injection into a stream of a liquid medium is presented. The aim was to investigate efficiency of such design of a magnetic device for application in magnetic targeting techniques. The presented construction was assembled from 10 magnetic elements having the same dimensions and residual magnetic field, and casing of Plexiglas material. Aggregating of clusters of FePt nanoparticles was evidently successful at preferable region located between two opposing parts of a magnetic device, which was tested for flow rates of (1 - 10) mL/min of main stream medium. To simulate the viscosity of blood a 1.5 % PVP 90 solution was used as the flowing medium. The shallow depth of targeting was chosen for practical reason: to ensure a maximum visibility of particle "steering" pattern obtainable by the magnetic device consisting of two adjacent parts comprising Halbach arrays.

• 出版日期2014