Absolute lymphocyte count at the end of induction therapy is a prognostic factor in childhood acute lymphoblastic leukemia

作者：Hirase Satoshi; Hasegawa Daiichiro^*; Takahashi Hironobu; Moriwaki Kensuke; Saito Atsuro; Kozaki Aiko; Ishida Toshiaki; Yanai Tomoko; Kawasaki Keiichiro; Yamamoto Nobuyuki; Kubokawa Ikuko; Mori Takeshi; Hayakawa Akira; Nishimura Noriyuki; Nishio Hisahide; Iijima Kazumoto; Kosaka Yoshiyuki

来源：International Journal of Hematology, 2015, 102(5): 594-601.

DOI：10.1007/s12185-015-1875-0

• Acute lymphoblastic leukemia
• Absolute lymphocyte count
• Childhood

Recent studies have reported that the absolute lymphocyte count (ALC) during induction therapy is predictive of treatment outcome in de novo acute lymphoblastic leukemia (ALL); however, the significance of ALC on outcomes remains controversial. In the present study, we assessed the significance of ALC at day 29 (ALC-29), the end of induction therapy, on outcomes in our Japanese cohort. The outcomes of 141 patients aged a parts per thousand currency sign18 years with newly diagnosed ALL who were enrolled on the JACLS ALL-02 at our hospitals were analyzed in terms of ALC-29. Patients with ALC-29 a parts per thousand yen750/mu L (n = 81) had a superior 5-year EFS (95.2 +/- A 2.7 vs 84.3 +/- A 4.8 %, P = 0.016) and OS (100 vs 87.0 +/- A 4.7 %, P = 0.0062). A multivariate analysis identified ALC-29 a parts per thousand yen750/mu L as a significant predictor of improved EFS and OS after controlling for confounding factors. A multiple linear regression model revealed a significant inverse relationship between the percentage of blasts in bone marrow on day 15 and ALC-29 (P = 0.005). These results indicate that ALC is a simple prognostic factor in childhood ALL, and, thus, has the potential to refine current risk algorithms.

• 出版日期2015-11