Antifungal activity of tetra-substituted tetrahydrofuran lignan, (-)-Virgatusin, and its structure-activity relationship

作者：Akiyama Koichi; Yamauchi Satoshi^*; Nakato Tomofumi; Maruyama Masafumi; Sugahara Takuya; Kishida Taro

来源：Bioscience Biotechnology and Biochemistry, 2007, 71(4): 1028-1035.

DOI：10.1271/bbb.60696

• virgatusin
• lignan
• antifungal activity

Antifungal activities of the optically pure (> 99%ee) (-)- and (+)-virgatusin, a tetra-substituted tetrahydrofuran lignan, were tested. (-)-Virgatusin, which is a natural product, showed highest antifungal activity against Colletotrichum lagenarium. Research on its structure-activity relationship was also performed. It was shown that two methoxy groups on 9 and 9' positions and a 3,4-methylenedioxyphenyl group on the 7 position of virgatusin were essential for high fungal growth inhibition. The part on 7'-phenyl group was not essential for activity. The 7'-(4-methoxyphenyl) derivative showed higher activity than that of (-)-virgatusin.

• 出版日期2007-4