Asymmetric Biocatalytic Amination of Ketones at the Expense of NH3 and Molecular Hydrogen

作者：Holzer Anja K; Hiebler Katharina; Mutti Francesco G; Simon Robert C; Lauterbach Lars; Lenz Oliver; Kroutil Wolfgang^*

来源：Organic Letters, 2015, 17(10): 2431-2433.

DOI：10.1021/acs.orglett.5b01154

A biocatalytic system is presented for the stereoselective amination of ketones at the expense of NH3 and molecular hydrogen. By using a NAD(+)-reducing hydrogenase, an alanine dehydrogenase, and a suitable omega-transaminase, the R- as well as the S-enantiomer of various amines could be prepared with up to >99% ee and 98% conversion.

• 出版日期2015-5-15