New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation

作者:Tu SJ*; Miao CB; Fang F; Feng YJ; Li TJ; Zhuang QY; Zhang XJ; Zhu SL; Shi DQ
来源:Bioorganic & Medicinal Chemistry Letters, 2004, 14(6): 1533-1536.
DOI:10.1016/j.bmcl.2003.12.092

摘要

The synthesis of bifunctional pyridine, pyrimidine, pyridone, quinoline and acridine derivatives was investigated using dialdehyde as a precursor. A rapid and efficient method was developed for the synthesis of a range of bifunctional monocyclic, bicyclic and tricycilc products related to 1,4-DHPs with the aim of finding new classes of biologically active compounds.