Antacid effects of Chinese herbal prescriptions assessed by a modified artificial stomach model

作者：Wu Tsung Hsiu; Chen I Chin; Chen Lih Chi^*

来源：World Journal of Gastroenterology, 2010, 16(35): 4455-4459.

DOI：10.3748/wjg.v16.i35.4455

• Traditional Chinese medicines
• Antacid
• Acid neutralizing capacity
• Artificial stomach

AIM To assess the antacid effects of the tonic Chinese herbal prescriptions, Si-Jun-Zi-Tang (SJZT) and Shen-Ling-Bai-Zhu San (SLBZS)
METHODS Decoctions of the tonic Chinese herbal prescriptions, SJZT and SLBZS, were prepared according to Chinese original documents The pH of the prescription decoctions and their neutralizing effects on artificial gastric acids were determined and compared with water and the active controls, sodium bicarbonate and colloidal aluminum phosphate A modified model of Vatier's artificial stomach was used to determine the duration of consistent neutralization effect on artificial gastric acids The neutralization capacity in vitro was determined with the titration method of Fordtran's model
RESULTS The results showed that both SJZT and SLBZS have antacid effects in vitro Compared with the water group, SJZT and SLBZS were found to possess significant gastric acid neutralizing effects The duration for consistent neutralization of SLBZS was significantly longer than that of water Also, SLBZS and SJZT exhibited significant antacid capacities compared to water

• 出版日期2010-9-21