Autofluorescence characteristics of suspicious choroidal nevi

作者：Chin Kimberly^*; Finger Paul T

来源：Optometry, 2009, 80(3): 126-130.

DOI：10.1016/j.optm.2008.07.018

• Autofluorescence
• Nevus
• Choroid
• Lipofuscin

PURPOSE: The aim of this study was to describe autofluorescence characteristics of 30 suspicious choroidal nevi.
METHODS: Fundus autofluorescence (FAF) images were reviewed retrospectively on 30 consecutive cases of suspicious choroidal nevi. Autofluorescence imaging was achieved using a fundus camera-based system with a barrier filter of 695 nm and excitation of 580 nm. All nevi exhibited one or more of the following characteristics: tumor thickness, basal dimension greater than 5 mm, subretinal fluid, posterior location, ophthalmic symptoms, or lipofuscin (orange pigment).
RESULTS: Suspicious choroidal nevi were found to have specific FAF features. Orange pigment was noted in 67% of the nevi and appeared as very bright hyperfluorescent areas. Overlying retinal pigment epithelium hypertrophy and atrophy were noted in 50% and appeared darkly hypofluorescent. Subretinal fluid (17%) and drusen (17%) both appeared mildly hyperfluorescent.
CONCLUSIONS: Orange pigment was the most hyperfluorescent FAF finding. Because the presence of orange pigment is a known risk factor for malignant transformation, the use of camera-based FAF imaging may improve our ability to identify those choroidal nevi that will transform into malignant melanoma. More long-term follow-up studies will be required to determine the exact prognostic value of our findings. Optometry 2009;80:126-130

• 出版日期2009-3