A method for mapping regional oxygen and CO2 transfer in the lung

作者：Johansen Troels^*; Winkler Tilo; Kelly Vanessa Jane; Osorio Valencia Juan Sebastian; Greenblatt Elliot Eliyahu; Harris Robert Scott; Venegas Jose Gabriel

来源：Respiratory Physiology & Neurobiology, 2016, 222: 29-47.

DOI：10.1016/j.resp.2015.10.017

• Pulmonary gas exchange
• Lung imaging
• O-2 uptake
• CO2 elimination
• Ventilation/perfusion
• Asthma

This paper presents a novel approach to visualizing regional lung function, through quantitative three-dimensional maps of O-2 and CO2 transfer rates. These maps describe the contribution of anatomical regions to overall gas exchange and demonstrate how transfer rates of the two gas species' differ regionally.
An algorithm for generating such maps is presented, and for illustration, regional gas transfer maps were generated using values of ventilation and perfusion imaged by PET/CT for a healthy subject and an asthmatic patient after bronchoprovocation.
In a sensitivity analysis, compartment values of gas transfer showed minor sensitivity to imaging noise in the ventilation and perfusion data, and moderate sensitivity to estimation errors in global lung input values, chiefly global alveolar ventilation, followed by cardiac output and arterial-venous O-2 content difference.
Gas transfer maps offer an intuitive display of physiologically relevant lung function at a regional level, the potential for an improved understanding of pulmonary gas exchange in health and disease, and potentially a presurgical evaluation tool.

• 出版日期2016-2-1
• 单位MIT