Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma

作者：Bockhorn M; Frilling A^*; Kalinin V; Schroder S; Broelsch CE

来源：Experimental and Clinical Endocrinology & Diabetes, 2000, 108(1): 49-53.

• ras oncogene
• sporadic medullary thyroid carcinoma
• multiple endocrine neoplasia 2

Medullary thyroid carcinoma (MTC) occurs sporadically (sMTC) or as part of the inherited cancer syndrome, multiple endocrine neoplasia type 2 (MEN 2). While the occurence of the MEN 2 syndrome is associated with mutations in the RET protooncogene, the reason for carcinogenesis in sMTC still remains unclear.
Ras is a frequently mutated oncogene in a broad spectrum of human tumors and has been found in about 50% of follicular, papillary or anaplastic thyroid carcinomas. The purpose of this study was to determine, whether mutations in the ras oncogene could play a possible role in the carcinogenesis of sMTC.
In this study we analyzed 15 sMTC for mutations in the hotspots codon 12, 13 and 61 of the H- and K-ras oncogene. We used the direct sequencing technique. In none of the examined tumors we were able to detect a mutation in the codon 12, 13 and 61 of the H-ras and K-ras oncogene.
Based upon these results, we conclude that H- and K-ras do not play an important role in the carcinogenesis of sMTC.

• 出版日期2000