An FP-CIT PET comparison of the difference in dopaminergic neuronal loss in subtypes of early Parkinson%26apos;s disease

作者：Song In Uk; Chung Yong An^*; Oh Jin Kyoung; Chung Sung Woo

来源：Acta Radiologica, 2014, 55(3): 366-371.

DOI：10.1177/0284185113498075

• Parkinson%26apos
• s disease
• tremor
• FP-CIT PET
• nigrostriatal dopaminergic system

Background Patients with tremor-dominant Parkinson%26apos;s disease (PD) have slower disease progression, show less cognitive decline, and have more favorable outcomes than patients with non-tremor PD. However, the pathophysiology of PD tremor remains unclear. Whether there are differences in nigrostriatal dopaminergic dysfunction between the two PD subtypes is unknown. %26lt;br%26gt;Purpose To evaluate the differences in regional dopamine transporter (DAT) density in the brain between different subtypes of early PD using FP-CIT PET/CT. %26lt;br%26gt;Material and Methods We recruited 43 patients with PD (21 tremor-dominant PD [TP] and 22 non-tremor-dominant PD [NTP]) and 18 age-matched healthy controls. All patients with PD underwent FP-CIT PET/CT imaging and evaluated Parkinsonian motor severity by using the Hoehn and Yahr stage and Part III of the Unified Parkinson%26apos;s Disease Rating Scale (UPDRS). We also compared tremor and non-tremor symptoms with motor phenotype scores between two subtypes of PD. %26lt;br%26gt;Results All patients with PD demonstrated a significantly decreased FP-CIT uptake in the putamen compared to healthy controls. Differences in putamen FP-CIT uptake versus caudate nucleus FP-CIT uptake in PD showed putamen uptake was significantly more impaired than that in the caudate nucleus. However, there was no significant difference in FP-CIT uptake in the striatum between both PD groups at the same early stage of disease. %26lt;br%26gt;Conclusion We suggest that differential of DAT uptake in the striatum did not allow for a reliable separation of subtypes into tremor-dominant and non-tremor-dominant, especially in the early stages of PD. Therefore, we assumed that many systems besides the nigrostriatal dopaminergic system are involved in the generation of tremors in PD.

• 出版日期2014-4