Artificial selection increased body weight but induced increase of runs of homozygosity in Hanwoo cattle

作者：Kim Kwondo; Jung Jaehoon; Caetano Anolles Kelsey; Sung Samsun; Yoo DongAhn; Choi Bong Hwan; Kim Hyung Chul^*; Jeong Jin Young; Cho Yong Min; Park Eung Woo; Choi Tae Jeong; Park Byoungho; Lim Dajeong^*; Kim Heebal^*

来源：PLos One, 2018, 13(3): e0193701.

DOI：10.1371/journal.pone.0193701

Artificial selection has been demonstrated to have a rapid and significant effect on the phenotype and genome of an organism. However, most previous studies on artificial selection have focused solely on genomic sequences modified by artificial selection or genomic sequences associated with a specific trait. In this study, we generated whole genome sequencing data of 126 cattle under artificial selection, and 24,973,862 single nucleotide variants to investigate the relationship among artificial selection, genomic sequences and trait. Using runs of homozygosity detected by the variants, we showed increase of inbreeding for decades, and at the same time demonstrated a little influence of recent inbreeding on body weight. Also, we could identify similar to 0.2 Mb runs of homozygosity segment which may be created by recent artificial selection. This approach may aid in development of genetic markers directly influenced by artificial selection, and provide insight into the process of artificial selection.

• 出版日期2018-3-21