How Molecular Testing Can Help (and Hurt) in the Workup of Gliomas

作者:Clark Kenneth; Voronovich Zoya; Horbinski Craig*
来源:American Journal of Clinical Pathology, 2013, 139(3): 275-288.
DOI:10.1309/AJCPFO8IIDNBIJ8Y

摘要

Advances in genetics research have greatly expanded our ability to accurately diagnose gliomas and provide more useful prognostic information. Herein specific examples are used to show how high-yield targets such as EGFR, 1p/19q, IDH1/2, MGMT, and BRAF can expand the power of the surgical neuropathologist. To avoid errors, however, the significance and controversies associated with each test must be thoroughly understood.

  • 出版日期2013-3