Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms

作者：Clemente Perez Alexandra; Makinson Stefanie Ritter; Higashikubo Bryan; Brovarney Scott; Cho Frances S; Urry Alexander; Holden Stephanie S; Wimer Matthew; David Csaba; Fenno Lief E; Acsady Laszlo; Deisseroth Karl; Paz Jeanne T

来源：Cell Reports, 2017, 19(10): 2130-2142.

DOI：10.1016/j.celrep.2017.05.044

Integrative brain functions depend on widely distributed, rhythmically coordinated computations. Through its long-ranging connections with cortex and most senses, the thalamus orchestrates the flow of cognitive and sensory information. Essential in this process, the nucleus reticularis thalami (nRT) gates different information streams through its extensive inhibition onto other thalamic nuclei, however, we lack an understanding of how different inhibitory neuron subpopulations in nRT function as gatekeepers. We dissociated the connectivity, physiology, and circuit functions of neurons within rodent nRT, based on parvalbumin (PV) and somatostatin (SOM) expression, and validated the existence of such populations in human nRT. We found that PV, but not SOM, cells are rhythmogenic, and that PV and SOM neurons are connected to and modulate distinct thalamocortical circuits. Notably, PV, but not SOM, neurons modulate somatosensory behavior and disrupt seizures. These results provide a conceptual framework for how nRT may gate incoming information to modulate brain-wide rhythms.

• 出版日期2017-6-6