A bioorthogonal Ga-68-labelling strategy for rapid in vivo imaging

作者：Evans Helen L; Quang De Nguyen; Carroll Laurence S; Kaliszczak Maciej; Twyman Frazer J; Spivey Alan C; Aboagye Eric O^*

来源：Chemical Communications, 2014, 50(67): 9557-9560.

DOI：10.1039/c4cc03903c

Herein, we describe a fast and robust method for achieving Ga-68-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels-Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy.

• 出版日期2014-8-28