Acid-degradable core-crosslinked micelles prepared from thermosensitive glycopolymers synthesized via RAFT polymerization

作者：Zhang Ling; Bernard Julien; Davis Thomas P; Barner Kowollik Christopher; Stenzel Martina H^*

来源：Macromolecular Rapid Communications, 2008, 29(2): 123-129.

DOI：10.1002/marc.200700663

• acid-degradable
• crosslinked micelle
• glycopolymer
• reversible addition fragmentation chain transfer (RAFT)
• stimuli-sensitive polymers

A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)-block-poly(N-isopropylacryamide) (PAGA(180)-b-PNIPAAM(350))was simultaneously self-assembled and cross-linked in aqueous medium via RAFT polymerization at 60 degrees C to afford core-crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli-responsive core. An acid-labile crosslinking agent, 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]-undecane, was employed to generate thermosensitive and acid-degradable core-shell nanoparticles. Stable against crosslinked micelles readily hydrolyzed block copolymers at lower pH (30 min and 12 h respectively pH = 2 and 4).

• 出版日期2008-1-17