Microwave-assisted α-halogenation of 2-methylquinolines with tetrabutylammonium iodide and 1,2-dichloroethane (1,2-dibromoethane)

作者：Xie, Yuanyuan^*; Li, Lehuan

来源：Tetrahedron Letters, 2014, 55(29): 3892-3895.

DOI：10.1016/j.tetlet.2014.04.023

• Halogenation
• 2-Methylquinolines
• Tetrabutylammonium iodide
• 1,2-Dichloroethane
• Microwave

A simple and efficient methodology permitting the halogenation of 2-methylquinolines into 2-(chloromethyl)quinolines or 2-(bromomethyl)quinolines in the tetrabutylammonium iodide and 1,2-dichloroethane (1,2-dibromoethane) system has been developed for the first time. The halogenation can be rapidly completed with good to excellent yields and high selectivity under microwave irradiation.

• 出版日期2014-7-16
• 单位浙江工业大学