An Efficient One-Pot Five-Component Tandem Sequential Approach for the Synthesis of Pyranopyrazole Derivatives via Suzuki Coupling and Multicomponent Reaction

作者：Lu, Zhangxiu; Xiao, Jinlong; Wang, Dongyang; Li, Yiqun^*

来源：Asian Journal of Organic Chemistry, 2015, 4(5): 487-492.

DOI：10.1002/ajoc.201500039

• arylboronic acids
• multicomponent reactions
• pyranopyrazoles
• Suzuki coupling
• tandem reactions

A one-pot tandem sequential protocol for efficient synthesis of a series of new pyranopyrazole derivatives has been developed involving Suzuki coupling of 4-bromobenzaldehyde and arylboronic acids followed by a four-component reaction from readily available ethyl acetoacetate, malononitrile, and hydrazine hydrate. All of the products were fully characterized by melting point, FTIR, (HNMR)-H-1, and (CNMR)-C-13 spectroscopy, and HRMS. The structure of one of the products was further established by X-ray diffraction analysis. This method should provide a useful strategy for the construction of pyranopyrazole heterocycles.

• 出版日期2015-5
• 单位暨南大学