Clinical Significance of MMP-2, MMP-9 and HIF-1 alpha Expression in Thyroid Micropapillary Cancer

作者：Choi Jae Young^*; Bae Ja Seong; Kim Young Ae; Chang Eun Deok; Cho Hang Joo; Kim Ki Hwan; Ahn Chang Hyeok; Park Woo Chan; Kim Jeong Soo

来源：Journal of the Korean Surgical Society, 2010, 78(3): 157-164.

DOI：10.4174/jkss.2010.78.3.157

• Thyroid carcinoma
• Papillary microcarcinoma
• MMP-2
• MMP-9
• HIF-1 alpha

Purpose: Papillary Thyroid Microcarcinoma (PTMC) is rapidly increasing (PTMC) to increased interests In the public health care system and Improvements in ultrasonographic Instruments and fine-needle-aspiration technique The aim of this study is to investigate relationships between clinicopathologic features and molecular markers of M-MC and to help in developing therapeutic Strategies in PTMC.
Methods: Tissue samples from patient:, with 38 PTMC and 21 benign thyroid tumors that were operated on from Jan. 2006 to Nov 2008 were Used to Make microarrays and immunohistochemcial staining for ER-alpha, E-CD, VEGF, MMP-2, MMP-9, and HIF-1 alpha were performed. Clinicopathologic features of each immunohistochemical staining group were analyzed retrospectively.
Results: There is no immunohistochemistry staining in cases with benign thyroid lesions. The expression rate of ER-alpha, E-CD, VEGF, MMP-2, MMP-9, and HIF-1 alpha in PTMC group was 66%, 58%, 82%, 66%, 71% and 63%, respectively. Bilateral tumor was statistically significant (48.0% vs 7.7%, P=0.015) related to MMP-2(+) PTMC group than in MMP-2(-) group. Bilateral tumor (44.4% vs 9.1%. P=0060) and lymphovascular invasion (25.9% vs 0%, P=0.084) seemed to have eater relation to MMP-9(+) PTMC group to MMP-9(-) group), but there is no statistically significant difference. Bilateral tumor (50.0% vs 7.1%, P=0.012), lymph node metastasis (45.8% vs 0%, P=0.003) and lymphovascular invasion (29.2% vs 0%, P=0.033) were significantly related to HIF-1 alpha(+) PTMC group compared to HIF-1 alpha(-) group.
Conclusion: Our findings suggest that MMP-2, MMP-9 and HIF-1 alpha expression could be used as a prognostic marker in PTMC. Larger studies are needed to assess its prognostic value in PTMC. (J Korean Surg Soc 2010;78:157-164)

• 出版日期2010-3