Adherence to Immunosuppressive Medication in Renal Transplant Recipients From Follow-up Outpatient in China: Association of 2 Different Measurement Methods

作者：Liu, Jia; Liu, Shan; Yan, Jin^*; Yi, Qifeng; Huang, Hui

来源：Clinical Therapeutics, 2015, 37(11): 2572-2580.

DOI：10.1016/j.clinthera.2015.09.014

• adherence
• immunosuppressive medication
• MMAS-4
• Morisky Medication Adherence Scale
• renal transplantation
• serum concentration

Purpose: Our aim was to investigate the association between self-report measure and serum concentration fluctuation of immunosuppressive medication (IM) in renal transplant recipients in China and examine the relationship between post-transplantation time and IM adherence.
Methods: Renal transplant recipients at least 3 months post transplantation were recruited from a follow-up outpatient clinic. Both self-reported Morisky Medication Adherence Scale and serum concentration of IM (cyclosporine trough level and tacrolimus trough level) were used to measure drug adherence.
Findings: Two hundred and nine patients were recruited in the study. The majority of the patients received grafts from deceased donors (70.3%), were male (63.2%), and were married (83.3%). The non-adherence to IM was 31.7%, as measured by the Morisky Medication Adherence Scale. A statistically significant association between self-reported adherence and serum concentration fluctuation of tacrolimus trough level was identified (P < 0.001), but not for cyclosporine (P = 0.997). Serum concentration fluctuation of tacrolimus trough levels and self-report adherence of IM were associated with transplantation time (P < 0.001 and P = 0.003, respectively).

• 出版日期2015-11
• 单位中南大学