Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume

作者：Madden David J^*; Parks Emily L; Tallman Catherine W; Boylan Maria A; Hoagey David A; Cocjin Sally B; Packard Lauren E; Johnson Micah A; Chou Ying hui; Potter Guy G; Chen Nan kuei; Siciliano Rachel E; Monge Zachary A; Honig Jesse A; Diaz Michele T

来源：Neurobiology of Aging, 2017, 54: 199-213.

DOI：10.1016/j.neurobiolaging.2017.01.027

• Magnetic resonance imaging
• Diffusion tensor imaging
• Cognition
• Cortex
• Mediation

Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.

• 出版日期2017-6